Instrumentation for multi-modal spectroscopic diagnosis of epithelial dysplasia

James W. Tunnell, Adrien E. Desjardins, Luis Galindo, Irene Georgakoudi, Sasha A. McGee, Jelena Mirkovic, Markus G. Mueller, Jon Nazemi, Freddy T. Nguyen, Adam Wax, Qingguo Zhang, Ramachandra R. Dasari, Michael S. Feld. Technology Cancer Research Treatment 2003-12-01

Full Text
Reflectance and fluorescence spectroscopies have shown great promise for early detection of epithelial dysplasia. We have developed a clinical reflectance spectrofluorimeter for multimodal spectroscopic diagnosis of epithelial dysplasia. This clinical instrument, the FastEEM, collects white light reflectance and fluorescence excitation-emission matrices (EEM's) within a fraction of a second. In this paper we describe the FastEEM instrumentation, designed for collection of multi-modal spectroscopic data. We illustrate its performance using tissue phantoms with well defined optical properties and biochemicals of known fluorescence properties. In addition, we discuss our plans to develop a system that combines a multi-spectral imaging device for wide area surveillance with this contact probe device.
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