In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy
Oliver Jonas, Jeon Woong Kang, Surya P. Singh, Alex Lammers, Freddy T. Nguyen, Ramachandra R. Dasari, Peter T. C. So, Robert Langer, Michael J. Cima. Analyst 2018-10-08
We describe a label-free approach based on Raman spectroscopy, to study drug-induced apoptosis in vivo. Spectral-shifts at wavenumbers associated with DNA, proteins, lipids, and collagen have been identified on breast and melanoma tumor tissues. These findings may enable a new analytical method for rapid readout of drug-therapy with miniaturized probes.