Freddy T. Nguyen, MD, PhD

Research Fellow @ Massachusetts Institute of Technology, Transfusion Medicine Fellow @ Dartmouth-Hitchcock Medical Center

In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy

In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy
Oliver Jonas, Jeon Woong Kang, Surya P. Singh, Alex Lammers, Freddy T. Nguyen, Ramachandra R. Dasari, Peter T. C. So, Robert Langer, Michael J. Cima. Analyst 2018-10-08

Full Text
We describe a label-free approach based on Raman spectroscopy, to study drug-induced apoptosis in vivo. Spectral-shifts at wavenumbers associated with DNA, proteins, lipids, and collagen have been identified on breast and melanoma tumor tissues. These findings may enable a new analytical method for rapid readout of drug-therapy with miniaturized probes.
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Physician-scientist with extensive experience developing and translating nanotechnologies and biomedical optical technologies from the bench to clinic in areas of genetics, oncology, and cardiovascular diseases. Extensive experience in community building in healthcare innovation, research, medical, and physician-scientist communities through various leadership roles.

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