Research Fellow @ Massachusetts Institute of Technology, Resident Physician @ Mount Sinai Hospital

Fourier Transform Light Scattering (FTLS) of Cells and Tissues

Huafeng Ding, Zhuo Wang, Freddy T. Nguyen, Stephen A. Boppart, Larry J. Millet, Martha U. Gillette, Jianming Liu, Marni D. Boppart, Gabriel Popescu. Journal of Computational and Theoretical Nanoscience 2010-12-01

Full Text
Fourier transform light scattering (FTLS) has been recently developed as a novel, ultrasensitive method for studying light scattering from inhomogeneous and dynamic structures. FTLS relies on quantifying the optical phase and amplitude associated with a coherent image field and propagating it numerically to the scattering plane. In this paper, we review the principle and applications of FTLS to static and dynamic light scattering from biological tissues and live cells. Compared with other existing light scattering techniques, FTLS has significant benefits of high sensitivity, speed, and angular resolution. We anticipate that FTLS will set the basis for disease diagnosis based on intrinsic tissue optical properties and provide an efficient tool for quantifying cell structures and dynamics.
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Physician-scientist with extensive experience developing and translating nanotechnologies and biomedical optical technologies from the bench to clinic in areas of genetics, oncology, and cardiovascular diseases. Extensive experience in community building in healthcare innovation, research, medical, and physician-scientist communities through various leadership roles.

Email: freddytn@mit.edu

Arnold O. Beckman Postdoctoral Fellow
Institute for Medical Engineering and Science

Research Fellow, MIT Innovation Initiative
Former Co-Director, MIT Hacking Medicine
Regional Director – Europe, MIT Hacking Medicine
Co-Director, MIT COVID-19 Challenge
Co-Director, MIT Hacking Racism Challenge

Massachusetts Institute of Technology
77 Massachusetts Avenue
Cambridge, MA 02139

Email: freddy.nguyen@mountsinai.org

Resident Physician, PGY-3,
Department of Pathology, Molecular and Cell-Based Medicine

Icahn School of Medicine at Mount Sinai
Mount Sinai Hospital
One Gustave L. Levy Place, Box 1194
New York, NY 10029