Research Fellow @ Massachusetts Institute of Technology, Resident Physician @ Mount Sinai Hospital

Coherent optical imaging and guided interventions in breast cancer: translating technology into clinical applications

Stephen A. Boppart, Freddy T. Nguyen, Adam M. Zysk, Eric J. Chaney, Jan G. Kotynek, Uretz J. Oliphant, Frank J. Bellafiore, Kendr, Patricia A. Johnson. Proc. SPIE 6991, Biophotonics: Photonic Solutions for Better Health Care, 699102 2008-04-17

Full Text
Breast cancer continues to be one of the most widely diagnosed forms of cancer in women and the second leading type of cancer deaths for women. The metastatic spread and staging of breast cancer is typically evaluated through the nodal assessment of the regional lymphatic system, and often this is performed during the surgical resection of the tumor mass. The recurrence rate of breast cancer is highly dependent on several factors including the complete removal of the primary tumor during surgery, and the presence of cancer cells in involved lymph nodes. Hence, developing means to more accurately resect tumor cells, along with the tumor mass, and ensure negative surgical margins, offers the potential to impact outcomes of breast cancer. The use of diffuse optical tomography has been applied for screening optical mammography applications as an alternative to standard x-ray mammography. The use of coherence ranging and coherent optical imaging in breast tissue has also found numerous applications, including intra-operative assessment of tumor margin status during lumpectomy procedures, assessment of lymph node changes for staging metastatic spread, and for guiding needle-biopsy procedures. The development, pre-clinical testing, and translation of techniques such as low-coherence interferometry (LCI) and optical coherence tomography (OCT) into clinical applications in breast cancer is demonstrated in these feasibility studies.
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Physician-scientist with extensive experience developing and translating nanotechnologies and biomedical optical technologies from the bench to clinic in areas of genetics, oncology, and cardiovascular diseases. Extensive experience in community building in healthcare innovation, research, medical, and physician-scientist communities through various leadership roles.

Email: freddytn@mit.edu

Arnold O. Beckman Postdoctoral Fellow
Institute for Medical Engineering and Science

Research Fellow, MIT Innovation Initiative
Former Co-Director, MIT Hacking Medicine
Regional Director – Europe, MIT Hacking Medicine
Co-Director, MIT COVID-19 Challenge
Co-Director, MIT Hacking Racism Challenge

Massachusetts Institute of Technology
77 Massachusetts Avenue
Cambridge, MA 02139

Email: freddy.nguyen@mountsinai.org

Resident Physician, PGY-3,
Department of Pathology, Molecular and Cell-Based Medicine

Icahn School of Medicine at Mount Sinai
Mount Sinai Hospital
One Gustave L. Levy Place, Box 1194
New York, NY 10029