Publications

2020
A Fiber Optic Interface Coupled to Nanosensors: Applications to Protein Aggregation and Organic Molecule Quantification, Kozawa, Daichi, Cho Soo-Yeon, Gong Xun, Nguyen Freddy T., Jin Xiaojia, Lee Michael A., Lee Heejin, Zeng Alicia, Xue Gang, Schacherl Jeff, et al. , ACS Nano, 2020/07/15, (2020)  (1.53 MB)
An Unsupervised Machine Learning Approach to Assess the ZIP Code Level Impact of COVID-19 in NYC, Khmaissia, Fadoua, Haghighi Pegah Sagheb, Jayaprakash Aarthe, Wu Zhenwei, Papadopoulos Sokratis, Lai Yuan, and Nguyen Freddy T. , 2020, (2020)  (1.5 MB)
2019
DNA-SWCNT Biosensors Allow Real-Time Monitoring of Therapeutic Responses in Pancreatic Ductal Adenocarcinoma., Bhattacharya, Santanu, Gong Xun, Wang Enfeng, Dutta Shamit K., Caplette Joseph R., Son Manki, Nguyen Freddy T., Strano Michael S., and Mukhopadhyay Debabrata , Cancer Res, 2019 09 01, Volume 79, Issue 17, p.4515-4523, (2019)  (944.05 KB)
Implanted Nanosensors in Marine Organisms for Physiological Biologging: Design, Feasibility, and Species Variability., Lee, Michael A., Nguyen Freddy T., Scott Kathleen, Chan Nathan Y. L., Bakh Naveed Ali, Jones Kelvin K., Pham Crystal, Garcia-Salinas Pablo, Garcia-Parraga Daniel, Fahlman Andreas, et al. , ACS Sens, 2019 01 25, Volume 4, Issue 1, p.32-43, (2019)  (6.62 MB)
2018
In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy., Jonas, Oliver, Kang Jeon Woong, Singh Surya P., Lammers Alex, Nguyen Freddy T., Dasari Ramachandra R., So Peter T. C., Langer Robert, and Cima Michael J. , Analyst, 2018 Oct 08, Volume 143, Issue 20, p.4836-4839, (2018)  (1.11 MB)
Characterization of magnetic nanoparticle-seeded microspheres for magnetomotive and multimodal imaging, Marjanovic, Marina, Nguyen Freddy T., Ahmad Adeel, Huang Pin-Chieh, Suslick Kenneth S., and Boppart Stephen , IEEE Journal of Selected Topics in Quantum Electronics, 2018 Jul, (2018)  (3.38 MB)
2016
Investigating Effects of Proteasome Inhibitor on Multiple Myeloma Cells Using Confocal Raman Microscopy., Kang, Jeon Woong, Singh Surya P., Nguyen Freddy T., Lue Niyom, Sung Yongjin, So Peter T. C., and Dasari Ramachandra R. , Sensors (Basel), 2016 Dec 14, Volume 16, Issue 12, (2016)  (1.97 MB)
2015
Low-coherence interferometry and optical coherence tomography for image-guided surgical treatment of solid tumors, Boppart, Stephen A., Nguyen Freddy T., and Zysk Adam M. , 2015 Mar 17, Number US 12/040,415, United States of America, (2015)  (3.12 MB)
High resolution live cell Raman imaging using subcellular organelle-targeting SERS-sensitive gold nanoparticles with highly narrow intra-nanogap., Kang, Jeon Woong, So Peter T. C., Dasari Ramachandra R., and Lim Dong-Kwon , Nano Lett, 2015 Mar 11, Volume 15, Issue 3, p.1766-72, (2015)  (6.08 MB)
Challenges and opportunities for reinvigorating the physician-scientist pipeline., Daye, Dania, Patel Chirag B., Ahn Jaimo, and Nguyen Freddy T. , J Clin Invest, 2015 Mar 02, Volume 125, Issue 3, p.883-7, (2015)  (200.96 KB)
Optical coherence tomography and targeted multi-modal protein microspheres for cancer imaging, Nguyen, Freddy T. , Chemistry, 03/2015, Volume PhD, Urbana, IL, p.231, (2015)  (42.24 MB)
2012
Targeted multifunctional multimodal protein-shell microspheres as cancer imaging contrast agents., John, Renu, Nguyen Freddy T., Kolbeck Kenneth J., Chaney Eric J., Marjanovic Marina, Suslick Kenneth S., and Boppart Stephen A. , Mol Imaging Biol, 2012 Feb, Volume 14, Issue 1, p.17-24, (2012)  (499.67 KB)
Measuring uptake dynamics of multiple identifiable carbon nanotube species via high-speed confocal Raman imaging of live cells., Kang, Jeon Woong, Nguyen Freddy T., Lue Niyom, Dasari Ramachandra R., and Heller Daniel A. , Nano Lett, 2012 Dec 12, Volume 12, Issue 12, p.6170-4, (2012)  (2.75 MB)
Toward a better understanding of the retention of physician-scientists in the career pipeline., Patel, Chirag B., Schauberger Eric M., and Nguyen Freddy T. , Acad Med, 2012 Apr, Volume 87, Issue 4, p.390-1; author reply 391, (2012)  (59.15 KB)
2011
Targeted multi-modal protein microspheres for cancer imaging, Nguyen, Freddy T., John Renu, Chaney Eric J., Suslick Kenneth S., and Boppart Stephen A. , Cancer Research, 2011 April 15, Volume 71, Issue 8 Supplement, p.4885, (2011)
Magnetomotive optical coherence microscopy for cell dynamics and biomechanics, Liang, Xing, Graf Benedikt W., John Renu, Crecea Vasilica, Nguyen Freddy T., Ding Huafeng, Song Hyon-min, Popescu Gabriel, Wei Alexander, and Boppart Stephen A. , 2011, Volume 7889, p.788926 - 788926-7, (2011)
2010
Congressionally Directed Medical Research Programs - Breast Cancer Research Program, , 2010 Sep, Fort Detrick, MD, (2010)  (2.63 MB)
Optical coherence tomography: the intraoperative assessment of lymph nodes in breast cancer., Nguyen, Freddy T., Zysk Adam M., Chaney Eric J., Adie Steven G., Kotynek Jan G., Oliphant Uretz J., Bellafiore Frank J., Rowland Kendrith M., Johnson Patricia A., and Boppart Stephen A. , IEEE Eng Med Biol Mag, 2010 Mar-Apr, Volume 29, Issue 2, p.63-70, (2010)  (1.22 MB)
Fourier Transform Light Scattering (FTLS) of Cells and Tissues, Ding, Huafeng, Wang Zhuo, Nguyen Freddy T., Boppart Stephen A., Millet Larry J., Gillette Martha U., Liu Jianming, Boppart Marni D., and Popescu Gabriel , Journal of Computational and Theoretical Nanoscience, 2010 Dec, Volume 7, Issue 12, p.2501-2511, (2010)  (857.32 KB)
Nanotube-porphyrin molecular structure and applications of same, Darsey, Jerry A., Buzatu Dan A., and Nguyen Freddy T. , 2010 Aug 24, Number US 11/225,371, United States of America, (2010)  (1.03 MB)
RGD coated protein microspheres as a dual fluorescent and magnetomotive contrast agent for targeted cancer imaging with magnetomotive optical coherence tomography, Nguyen, Freddy T., John Renu, Chaney Eric J., Dibbern Elizabeth M., Suslick Kenneth S., and Boppart Stephen A. , Cancer Research, 2010 April 15, Volume 70, Issue 8 Supplement, p.4559, (2010)
2009
Clinical feasibility of microscopically-guided breast needle biopsy using a fiber-optic probe with computer-aided detection., Zysk, Adam M., Nguyen Freddy T., Chaney Eric J., Kotynek Jan G., Oliphant Uretz J., Bellafiore Frank J., Johnson Patricia A., Rowland Kendrith M., and Boppart Stephen A. , Technol Cancer Res Treat, 2009 Oct, Volume 8, Issue 5, p.315-21, (2009)  (1.58 MB)
Intraoperative evaluation of breast tumor margins with optical coherence tomography., Nguyen, Freddy T., Zysk Adam M., Chaney Eric J., Kotynek Jan G., Oliphant Uretz J., Bellafiore Frank J., Rowland Kendrith M., Johnson Patricia A., and Boppart Stephen A. , Cancer Res, 2009 Nov 15, Volume 69, Issue 22, p.8790-6, (2009)  (1.04 MB)
Translational careers., Andrews, N, Burris J E., Cech T R., Coller B S., Crowley W F., Gallin E K., Kelner K L., Kirch D G., Leshner A I., Morris C D., et al. , Science, 2009 May 15, Volume 324, Issue 5929, p.855, (2009)  (80.42 KB)
Optical properties of tissues quantified by Fourier-transform light scattering., Ding, Huafeng, Nguyen Freddy, Boppart Stephen A., and Popescu Gabriel , Opt Lett, 2009 May 01, Volume 34, Issue 9, p.1372-4, (2009)  (319.34 KB)
Optical coherence tomography (OCT) as a diagnostic tool for the real-time intraoperative assessment of breast cancer surgical margins., Nguyen, Freddy T., Zysk Adam M., Chaney Eric J., Kotynek Jan G., Oliphant Uretz J., Bellafiore Frank J., Rowland Kendrith M., Johnson Patricia A., and Boppart Stephen A. , Cancer Research, 2009 January 15, Volume 69, Issue 2 Supplement, p.802, (2009)
Restructuring MD-PhD programs: career training or broad education?, Ahn, Jaimo, Nguyen Freddy T., Mann Jason R., and M O'Banion Kerry , Acad Med, 2009 Apr, Volume 84, Issue 4, p.407; author reply 407-8, (2009)  (32.83 KB)
2008
Nonprofit World, , Science, 2008 May 9, Volume 320, Issue 5877, p.727, (2008)  (116.25 KB)
Medical Student Attitudes and Perceptions on the USMLE Review, Nguyen, Freddy T., and Schauberger Eric M. , 2008 Mar, (2008)  (362.71 KB)
Fourier transform light scattering of inhomogeneous and dynamic structures., Ding, Huafeng, Wang Zhuo, Nguyen Freddy, Boppart Stephen A., and Popescu Gabriel , Phys Rev Lett, 2008 Dec 05, Volume 101, Issue 23, p.238102, (2008)  (1.77 MB)
The birth of the American Physician Scientists Association--the next generation of Young Turks., Nguyen, Freddy T. , J Clin Invest, 2008 Apr, Volume 118, Issue 4, p.1237-40, (2008)  (443.57 KB)
Magnetic protein microspheres as dynamic contrast agents for magnetomotive optical coherence tomography, Nguyen, Freddy T., Dibbern Elizabeth M., Chaney Eric J., Oldenburg Amy L., Suslick Kenneth S., and Boppart Stephen A. , 2008, Volume 6867, p.68670F - 68670F-11, (2008)
Coherent optical imaging and guided interventions in breast cancer: translating technology into clinical applications, Boppart, Stephen A., Nguyen Freddy T., Zysk Adam M., Chaney Eric J., Kotynek Jan G., Oliphant Uretz J., Bellafiore Frank J., Rowland Kendrith M., and Johnson Patricia A. , 2008, Volume 6991, p.699102 - 699102-12, (2008)
Association of Professors of Medicine Physician-Scientist Initiative: Recommendations for Revitalizing the Nation’s Physician-Scientist Workforce, , 2008, Washington, DC, USA, (2008)  (621.94 KB)
2007
Optical coherence tomography: a review of clinical development from bench to bedside., Zysk, Adam M., Nguyen Freddy T., Oldenburg Amy L., Marks Daniel L., and Boppart Stephen A. , J Biomed Opt, 2007 Sep-Oct, Volume 12, Issue 5, p.051403, (2007)  (939.2 KB)
Intraoperative Needle-Based Refractive Index Measurement of ex vivo Human Breast Tissue, Zysk, Adam M., Marks Daniel L., Nguyen Freddy T., Kotynek Jan G., Bellafiore Frank J., Johnson Patricia A., Rowland Kendrith M., and Boppart Stephen A. , Frontiers in Optics 2007/Laser Science XXIII/Organic Materials and Devices for Displays and Energy ConversionFrontiers in Optics 2007/Laser Science XXIII/Organic Materials and Devices for Displays and Energy Conversion, 2007 Sep 16, San Jose, California, p.FWV4, (2007)
Needle-based refractive index measurement using low-coherence interferometry., Zysk, Adam M., Adie Steven G., Armstrong Julian J., Leigh Matthew S., Paduch Alexandre, Sampson David D., Nguyen Freddy T., and Boppart Stephen A. , Opt Lett, 2007 Feb 15, Volume 32, Issue 4, p.385-7, (2007)  (144.22 KB)
Interferometric synthetic aperture microscopy., Ralston, Tyler S., Marks Daniel L., P Carney Scott, and Boppart Stephen A. , Nat Phys, 2007 Feb 01, Volume 3, Issue 2, p.129-134, (2007)  (994.3 KB)
Multimodal biomedical imaging with asymmetric single-walled carbon nanotube/iron oxide nanoparticle complexes., Choi, Jong Hyun, Nguyen Freddy T., Barone Paul W., Heller Daniel A., Moll Anthonie E., Patel Dhaval, Boppart Stephen A., and Strano Michael S. , Nano Lett, 2007 Apr, Volume 7, Issue 4, p.861-7, (2007)  (307.89 KB)
Portable real-time optical coherence tomography system for intraoperative imaging and staging of breast cancer, Nguyen, Freddy T., Zysk Adam M., Kotynek Jan G., Bellafiore Frank J., Rowland Kendrith M., Johnson Patricia A., Chaney Eric J., and Boppart Stephen A. , 2007, Volume 6430, p.64300H - 64300H-10, (2007)
Needle-probe system for the measurement of tissue refractive index, Zysk, Adam M., Adie Steven G., Armstrong Julian J., Leigh Matthew S., Paduch Alexandre, Nguyen Freddy T., Sampson David D., and Boppart Stephen A. , 2007, Volume 6430, p.64300O - 64300O-8, (2007)
2006
Three-Dimensional Visualization of Lymph Node Morphology Using OCT, Nguyen, Freddy T., Luo Wei, Zysk Adam M., Ralston Tyler S., Chaney Eric J., Marks Daniel L., Oldenburg Amy L., Brockenbrough John, and Boppart Stephen A. , Biomedical Optics, 2006/03/19, Fort Lauderdale, Florida, p.SH2, (2006)
2005
Optical biopsy of lymph node morphology using optical coherence tomography., Luo, Wei, Nguyen Freddy T., Zysk Adam M., Ralston Tyler S., Brockenbrough John, Marks Daniel L., Oldenburg Amy L., and Boppart Stephen A. , Technol Cancer Res Treat, 2005 Oct, Volume 4, Issue 5, p.539-48, (2005)  (355.85 KB)
Color-blind fluorescence detection for four-color DNA sequencing., Lewis, Ernest K., Haaland Wade C., Nguyen Freddy, Heller Daniel A., Allen Matthew J., MacGregor Robert R., C Berger Scott, Willingham Britain, Burns Lori A., Scott Graham B. I., et al. , Proc Natl Acad Sci U S A, 2005 Apr 12, Volume 102, Issue 15, p.5346-51, (2005)  (547.76 KB)
2004
Computational Analysis of Transition Metal Doped Nanotubes and Their Application to Molecular Electronics, Buzatu, Dan A., Nguyen Freddy T., Reddy Shreedhar N., and Darsey Jerry A. , Journal of Computational and Theoretical Nanoscience, 2004 Mar, Volume 1, Issue 1, p.99-105, (2004)  (408.79 KB)
2003
Instrumentation for multi-modal spectroscopic diagnosis of epithelial dysplasia., Tunnell, J W., Desjardins A E., Galindo L, Georgakoudi I, McGee S A., Mirkovic J, Mueller M G., Nazemi J, Nguyen F T., Wax A, et al. , Technol Cancer Res Treat, 2003 Dec, Volume 2, Issue 6, p.505-14, (2003)  (876.19 KB)
2001
Electron transfer to oriented molecules: Surprising steric effect in t-butyl bromide, Harris, Sean A., and Brooks Philip R. , The Journal of Chemical Physics, 2001 Jun 11, Volume 114, Issue 24, p.10569-10572, (2001)  (53.18 KB)