In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy

TitleIn vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy
Publication TypeJournal Article
Year of Publication2018
AuthorsJonas, Oliver, Kang Jeon Woong, Singh Surya P., Lammers Alex, Nguyen Freddy T., Dasari Ramachandra R., So Peter T. C., Langer Robert, and Cima Michael J.
JournalAnalyst
Date Published2018 Aug 02
ISSN1364-5528
Abstract

We describe a label-free approach based on Raman spectroscopy, to study drug-induced apoptosis in vivo. Spectral-shifts at wavenumbers associated with DNA, proteins, lipids, and collagen have been identified on breast and melanoma tumor tissues. These findings may enable a new analytical method for rapid readout of drug-therapy with miniaturized probes.

DOI10.1039/c8an00913a
Alternate JournalAnalyst
PubMed ID30070266