Fourier Transform Light Scattering (FTLS) of Cells and Tissues

TitleFourier Transform Light Scattering (FTLS) of Cells and Tissues
Publication TypeJournal Article
Year of Publication2010
AuthorsDing, Huafeng, Wang Zhuo, Nguyen Freddy T., Boppart Stephen A., Millet Larry J., Gillette Martha U., Liu Jianming, Boppart Marni D., and Popescu Gabriel
JournalJournal of Computational and Theoretical Nanoscience
Volume7
Issue12
Pagination2501-2511
Date Published2010 Dec
KeywordsFOURIER TRANSFORM LIGHT SCATTERING; QUANTITATIVE PHASE MICROSCOPY; SCATTERING; PHASE; TISSUE; CELLS
Abstract

Fourier transform light scattering (FTLS) has been recently developed as a novel, ultrasensitive method for studying light scattering from inhomogeneous and dynamic structures. FTLS relies on quantifying the optical phase and amplitude associated with a coherent image field and propagating it numerically to the scattering plane. In this paper, we review the principle and applications of FTLS to static and dynamic light scattering from biological tissues and live cells. Compared with other existing light scattering techniques, FTLS has significant benefits of high sensitivity, speed, and angular resolution. We anticipate that FTLS will set the basis for disease diagnosis based on intrinsic tissue optical properties and provide an efficient tool for quantifying cell structures and dynamics.

URLhttp://dx.doi.org/10.1166/jctn.2010.1637
DOI10.1166/jctn.2010.1637