Needle-based refractive index measurement using low-coherence interferometry.

TitleNeedle-based refractive index measurement using low-coherence interferometry.
Publication TypeJournal Article
Year of Publication2007
AuthorsZysk, Adam M., Adie Steven G., Armstrong Julian J., Leigh Matthew S., Paduch Alexandre, Sampson David D., Nguyen Freddy T., and Boppart Stephen A.
JournalOpt Lett
Date Published2007 Feb 15
KeywordsEquipment Design, Equipment Failure Analysis, Fiber Optic Technology, Image Enhancement, Interferometry, Needles, Refractometry, Reproducibility of Results, Sensitivity and Specificity, Tomography, Optical Coherence, Transducers

We present a novel needle-based device for the measurement of refractive index and scattering using low-coherence interferometry. Coupled to the sample arm of an optical coherence tomography system, the device detects the scattering response of, and optical path length through, a sample residing in a fixed-width channel. We report use of the device to make near-infrared measurements of tissues and materials with known optical properties. The device could be used to exploit the refractive index variations of tissue for medical and biological diagnostics accessible by needle insertion.

Alternate JournalOpt Lett
PubMed ID17356661