Instrumentation for multi-modal spectroscopic diagnosis of epithelial dysplasia.

TitleInstrumentation for multi-modal spectroscopic diagnosis of epithelial dysplasia.
Publication TypeJournal Article
Year of Publication2003
AuthorsTunnell, J W., Desjardins A E., Galindo L, Georgakoudi I, McGee S A., Mirkovic J, Mueller M G., Nazemi J, Nguyen F T., Wax A, Zhang Q, Dasari R R., and Feld M S.
JournalTechnol Cancer Res Treat
Volume2
Issue6
Pagination505-14
Date Published2003 Dec
ISSN1533-0346
KeywordsCarcinoma, Epithelium, Fiber Optic Technology, Humans, Optics and Photonics, Phantoms, Imaging, Software, Spectrometry, Fluorescence, Spectrum Analysis
Abstract

Reflectance and fluorescence spectroscopies have shown great promise for early detection of epithelial dysplasia. We have developed a clinical reflectance spectrofluorimeter for multimodal spectroscopic diagnosis of epithelial dysplasia. This clinical instrument, the FastEEM, collects white light reflectance and fluorescence excitation-emission matrices (EEM's) within a fraction of a second. In this paper we describe the FastEEM instrumentation, designed for collection of multi-modal spectroscopic data. We illustrate its performance using tissue phantoms with well defined optical properties and biochemicals of known fluorescence properties. In addition, we discuss our plans to develop a system that combines a multi-spectral imaging device for wide area surveillance with this contact probe device.

DOI10.1177/153303460300200603
Alternate JournalTechnol. Cancer Res. Treat.
PubMed ID14640762
Grant ListP41-RR02594 / RR / NCRR NIH HHS / United States
R01-CA97966 / CA / NCI NIH HHS / United States